Diazepam is usually only recommended for a short period of time of up to 4 weeks. In addition, the facility should attempt periodic tapering of the medication or provide documentation of medical necessity in accordance with OBRA guidelines. If oxycodone is initiated in a patient taking a benzodiazepine, reduce dosages and titrate to clinical response. For children: Keep this drug out of the reach of children. It can also cause your breathing to slow down or stop.
Keep person on the side facing you, note time given and continue to observe. Benzodiazepines may also cause incoordination or paradoxical reactions that may worsen symptoms of Parkinson’s disease. Caution patients against use of alcohol during treatment with benzodiazepines. Succinylcholine: Moderate Concurrent use of benzodiazepines and other CNS active medications including neuromuscular blockers, can potentiate the CNS effects of either agent. In addition, worsening of depressive symptoms may occur during diazepam administration. If you do take diazepam while you’re breastfeeding and you notice that your baby’s not feeding as well as usual, seems unusually sleepy, has unusual breathing, or you have any other concerns about them, talk to your health visitor or doctor as soon as possible. Erythromycin; Sulfisoxazole: Moderate Erythromycin may inhibit the CYP3A4-mediated metabolism of oxidized benzodiazepines, such as diazepam. Drugs that are largely eliminated via CYP2C19 metabolism, such as diazepam, may have prolonged elimination upon co-administration of modafinil. Tobacco: Moderate Tobacco smoke contains polycyclic aromatic hydrocarbons that induce hepatic CYP microsomal enzymes; tobacco smoking may thus increase the clearance of selected drugs.
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If occasional maternal therapy with a benzodiazepine is required, lorazepam or oxazepam may be reasonable alternatives for some patients. Lofexidine can potentiate the effects of CNS depressants such as benzodiazepines. Because of possible additive effects, advise patients about the potential for increased somnolence during concurrent use of safinamide with other sedating medications, such as benzodiazepines. Patients receiving rifampin may require higher doses of diazepam to achieve the desired clinical effect. Never take 2 doses at the same time.