Garnol, R. It is highly probable that, as in the case of the skeletal muscles of rats [ 8 ], one of the causes of OS in the salivary glands is increased mitochondrial and cytoplasmic ROS production, which exceeds the antioxidant capacity of these glands. MCP-1 has a chemotactic effect on monocytes that flow to the adipose tissue and are transformed in tissue resident inflammatory M1 phenotype macrophage [ 53 ]. Introduction One of the most important problems of modern diabetology is a growing incidence of type 2 diabetes. Evidence showed that the parotid not the submandibular glands are highly aerobic organs and have a highly efficient mitochondrial antioxidant system, comparable to that of liver mitochondria, capable of scavenging a large part of the produced ROS [ 47, 48 ]. The level of peroxynitrite was analyzed colorimetrically based on peroxynitrite-mediated nitration resulting in the formation of nitrophenol [ 34 ]. The ingestion of a HFD has been shown to promote fatty acid oxidation due to changes in the fat composition of Mt and impaired oxidative phosphorylation [ 17 ].
The effects of the diet. Estabrook RW.
Plasma leptin: associations with metabolic, inflammatory and haemostatic risk factors for cardiovascular disease. In the present study, the influence of the ingestion of a high-fat diet HFD on superoxide anion generation in rat liver mitochondria Mt and membrane fluidity was investigated. Liver Mt were isolated and oxygen consumption, superoxide anion production the adrenaline method, and membrane fluidity the spin label method were measured. Bearing in mind the proven role of oxidative stress in salivary gland dysfunction in the course of IR induced by a high-fat diet and the role of salivary glands in maintaining redox homeostasis, it seems important to learn about the mechanisms leading to disrupting this balance. Revised 30 May
Abstract Oxidative stress plays a crucial role in the salivary gland dysfunction in insulin resistance; however, the cause of increased free anion formation in these conditions is still unknown. Twelve male Diet rats were fa as experimental animals in the present study. Download citation. Analyzing the results fat lipid peroxidation in the liver, there was no difference among all high groups Fig. Springer And remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Liu, and Superoxide. Metabolic sources of reactive oxygen metabolites during oxidant stress and ischemia with reperfusion. The statistical significance was defined as. Hugo, M.